Persistent depressive disorder, also called dysthymia, is a form of continuous and long-term (chronic) depression. It is possible that you lose interest in the normal activities of daily life, feel hopeless, become unproductive and have low self-esteem and a general sense of ineptitude. These feelings last for years and can greatly affect your relationships and your performance at the academic institution and in office. If you have a persistent depressive disorder, you may find it difficult to feel optimistic even on happy occasions. It may largely be described as pessimistic or negative, for those who believe that complaining all the time or being unable to have fun, are choices rather than illness.