Titers are used to prove immunity to a disease. A blood sample is taken and tested. If the test is positive, the individual has immunity. If the test is negative or equivocal, you need to be vaccinated. Vaccine titer test is used to measure the existence and level of antibodies to a disease in your blood. Antibodies are produced when an antigen provokes a response from the immune system. Vaccine titer is a multifaceted immunity process involving antigen processing, humoral immunity, cell-mediated immunity, local immunity and cell memory.